| Italy v France Stadio Olimpico, Rome Saturday, 6 February, 2021 @ 14:15 |
Referee: Matthew Carley (RFU) |
| England v Scotland Twickenham Stadium, London Saturday 6 February 2021 @ 16:45 |
Referee: Andrew Brace (IRFU) Assistant Referee 1: Pascal Gauzere (FFR) Assistant Referee 2: Mathieu Raynal (FFR) TMO: Joy Neville (IRFU) |
| Wales v Ireland Principality Stadium, Cardiff Sunday, 7 February, 2021 @ 15:00 |
Referee: Wayne Barnes (RFU) Assistant Referee 1: Luke Pearce (RFU) Assistant Referee 2: Alex Ruiz (FFR) TMO: Tom Foley (RFU) |
| England v Italy Twickenham Stadium, London Saturday, 13 February, 2021 @ 14:15 |
Referee: Mike Adamson (SRU) Assistant Referee 1: Romain Poite (FFR) Assistant Referee 2: Ben Blain (SRU) TMO: Joy Neville (IRFU) |
| Scotland v Wales BT Murrayfield Stadium, Edinburgh Saturday, 13 February, 2021 @ 16:45 |
Referee: Matthew Carley (RFU) Assistant Referee 1: Pascal Gauzere (FFR) Assistant Referee 2: Andrea Piardi (FIR) TMO: Karl Dickson (RFU) |
| Ireland v France Aviva Stadium, Dublin Sunday, 14 February, 2021 @ 15:00 |
Referee: Luke Pearce (RFU) Assistant Referee 1: Wayne Barnes (RFU) Assistant Referee 2: Christophe Ridley (RFU) TMO: Tom Foley (RFU) |
| Italy v Ireland Stadio Olimpico, Rome Saturday, 27 February, 2021 @ 14:15 |
Referee: Mathieu Raynal (FFR) Assistant Referee 1: Mike Adamson (SRU) Assistant Referee 2: Craig Evans (WRU) TMO: Romain Poite (FFR) |
| Wales v England Principality Stadium, Cardiff Saturday 27 February 2021 @ 1645 |
Referee: Pascal Gauzere (FFR) Assistant Referee 1: Andrew Brace (IRFU) Assistant Referee 2: Frank Murphy (IRFU) TMO: Alex Ruiz (FFR) |
| Italy v Wales Stadio Olimpico, Rome Saturday, 13 March, 2021 @ 14:15 |
Referee: Wayne Barnes (RFU) Assistant Referee 1: Pascal Gauzere (FFR) Assistant Referee 2: Christophe Ridley (RFU) TMO: Tom Foley (RFU) |
| England v France Twickenham Stadium, London Saturday, 13 March, 2021 @ 16:45 |
Referee: Andrew Brace (IRFU) Assistant Referee 1: Mike Adamson (SRU) Assistant Referee 2: Frank Murphy (IRFU) TMO: Joy Neville (IRFU) |
| Scotland v Ireland BT Murrayfield, Edinburgh Sunday, 14 March, 2021 @ 15:00 |
Referee: Romain Poite (FFR) Assistant Referee 1: Mathieu Raynal (FFR) Assistant Referee 2: Andrea Piardi (FIR) TMO: Alex Ruiz (FFR) |
| Scotland v Italy BT Murrayfield, Edinburgh Saturday, 20 March, 2021 @ 14:15 |
Referee: Pascal Gauzere (FFR) Assistant Referee 1: Karl Dickson (RFU) Assistant Referee 2: Ben Whitehouse (WRU) TMO: Alex Ruiz (FFR) |
| Ireland v England Aviva Stadium, Dublin Saturday, 20 March, 2021 @ 16:45 |
Referee: Mathieu Raynal (FFR) Assistant Referee 1: Mike Adamson (SRU) Assistant Referee 2: Craig Evans (WRU) TMO: Romain Poite (FFR) |
| France v Wales Stade de France, Paris Saturday, 20 March, 2021 @ 20:00 |
Referee: Luke Pearce (RFU) Assistant Referee 1: Matthew Carley (RFU) Assistant Referee 2: Christophe Ridley (RFU) TMO: Wayne Barnes (RFU) |
|
France v Scotland (Rescheduled) |
Referee: Wayne Barnes (RFU) Assistant Referee 1: Matthew Carley (RFU) Assistant Referee 2: Andrea Piardi (FIR) TMO: Tom Foley (RFU) |