Ireland v Wales
Aviva Stadium, Dublin
Saturday, 5 February, 2022		 Referee: Jaco Peyper (SARU)
Assistant Referee 1: Mathieu Raynal (FFR)
Assistant Referee 2: Angus Gardner (RA)
TMO: Stuart Terheege (RFU)
Scotland v England
BT Murrayfield, Edinburgh
Saturday, 5 February, 2022		 Referee: Ben O'Keeffe (NZR)
Assistant Referee 1: Nic Berry (RA)
Assistant Referee 2: Craig Evans (WRU)
TMO: Ben Whitehouse (WRU)
France v Italy
Stade de France, Paris
Sunday, 6 February, 2022		 Referee: Mike Adamson (SRU)
Assistant Referee 1: Nika Amashukeli (GRU)
Assistant Referee 2: Damon Murphy (RA)
TMO: Brett Cronan (RA)
Wales v Scotland
Principality Stadium, Cardiff
Saturday, 12 February, 2022		 Referee: Nic Berry (RA)
Assistant Referee 1: Wayne Barnes (RFU)
Assistant Referee 2: Chris Busby (IRFU)
TMO: Brett Cronan (RA)
France v Ireland
Stade de France, Paris
Saturday, 12 February, 2022		 Referee: Angus Gardner (RA)
Assistant Referee 1: Ben O'Keeffe (NZR)
Assistant Referee 2: Craig Evans (WRU)
TMO: Ben Whitehouse (WRU)
Italy v England
Stadio Olimpico, Rome
Sunday, 13 February, 2022		 Referee: Damon Murphy (RA)
Assistant Referee 1: Andrew Brace (IRFU)
Assistant Referee 2: Pierre Brousset (FFR)
TMO: Brian MacNeice (IRFU)
Scotland v France
BT Murrayfield, Edinburgh
Saturday, 26 February, 2022		 Referee: Karl Dickson (RFU)
Assistant Referee 1: Luke Pearce (RFU)
Assistant Referee 2: Chris Busby (IRFU)
TMO: Tom Foley (RFU)
England v Wales
Twickenham Stadium, London
Saturday, 26 February, 2022		 Referee: Mike Adamson (SRU)
Assistant Referee 1: Mathieu Raynal (FFR)
Assistant Referee 2: Frank Murphy (IRFU)
TMO: Brian MacNeice (IRFU)
Ireland v Italy
Aviva Stadium, Dublin
Sunday, 27 February, 2022		 Referee: Nika Amashukeli (GRU)
Assistant Referee 1: Matthew Carley (RFU)
Assistant Referee 2: Christophe Ridley (RFU)
TMO: Eric Gauzins (FFR)
Wales v France
Principality Stadium, Cardiff
Friday, 11 March, 2022		 Referee: Matthew Carley (RFU)
Assistant Referee 1: Jaco Peyper (SARU)
Assistant Referee 2: Andrea Piardi (FIR)
TMO: Tom Foley (RFU)
Italy v Scotland
Stadio Olimpico, Rome
Saturday, 12 March, 2022		 Referee: Luke Pearce (RFU)
Assistant Referee 1: Andrew Brace (IRFU)
Assistant Referee 2: Craig Evans (WRU)
TMO: Stuart Terheege (RFU)
England v Ireland
Twickenham Stadium, London
Saturday, 12 March, 2022		 Referee: Mathieu Raynal (FFR)
Assistant Referee 1: Mike Adamson (SRU)
Assistant Referee 2: Pierre Brousset (FFR)
TMO: Marius Jonker (SARU)
Wales v Italy
Principality Stadium, Cardiff
Saturday, 19 March, 2022		 Referee: Andrew Brace (IRFU)
Assistant Referee 1: Matthew Carley (RFU)
Assistant Referee 2: Tual Trainini (FFR)
TMO: Joy Neville (IRFU)
Ireland v Scotland
Aviva Stadium, Dublin
Saturday, 19 March, 2022		 Referee: Wayne Barnes (RFU)
Assistant Referee 1: Karl Dickson (RFU)
Assistant Referee 2: Christophe Ridley (RFU)
TMO: Stuart Terheege (RFU)
France v England
Stade de France, Paris
Saturday, 19 March, 2022		 Referee: Jaco Peyper (SARU)
Assistant Referee 1: Mike Adamson (SRU)
Assistant Referee 2: Frank Murphy (IRFU)
TMO: Marius Jonker (SARU)