| England v New Zealand Sandy Park, Exeter Sunday, 31 October, 2021 |
Referee: Aimee Barrett-Theron (SARU) Assistant Referee 1: Aurelie Groizeleau (FFR) Assistant Referee 2: Clara Munarini (FIR) TMO: Ben Whitehouse (WRU) |
| France v South Africa Stade de la Rabine, Vannes Saturday, 6 November, 2021 |
Referee: Sara Cox (RFU) Assistant Referee 1: Hollie Davidson (SRU) Assistant Referee 2: Katherine Ritchie (RFU) TMO: Claire Hodnett (RFU) |
| Wales v Japan Cardiff Arms Park, Cardiff Sunday, 7 November, 2021 |
Referee: Clara Munarini (FIR) Assistant Referee 1: Maria Beatrice Benvenuti (FIR) Assistant Referee 2: Maria Giovanna Pacifico (FIR) TMO: Stefano Penne (FIR) |
| England v New Zealand Franklin's Gardens, Northampton Sunday, 7 November, 2021 |
Referee: Aurelie Groizeleau (FFR) Assistant Referee 1: Aimee Barrett-Theron (SARU) Assistant Referee 2: Doriane Domenjo (FFR) TMO: Eric Gauzins (FFR) |
| Ireland v USA RDS Stadium, Dublin Friday, 12 November, 2021 |
Referee: Sara Cox (RFU) Assistant Referee 1: Maria Beatrice Benvenuti (FIR) Assistant Referee 2: Maria Giovanna Pacifico (FIR) TMO: Claire Hodnett (RFU) |
| Wales v South Africa Cardiff Arms Park, Cardiff Saturday, 13 November, 2021 |
Referee: Clara Munarini (FIR) Assistant Referee 1: Doriane Domenjo (FFR) Assistant Referee 2: Maria Latos (Ger) TMO: Ian Tempest (RFU) |
| France v New Zealand Stade du Hameau, Pau Saturday, 13 November, 2021 |
Referee: Aimee Barrett-Theron (SARU) Assistant Referee 1: Sam Grove-White (SRU) Assistant Referee 2: Katherine Ritchie (RFU) TMO: Ben Whitehouse (WRU) |
| Scotland v Japan DAM Health Stadium, Murrayfield Sunday, 14 November, 2021 |
Referee: Nikki O'Donnell (RFU) Assistant Referee 1: Sara Cox (RFU) Assistant Referee 2: Francesca Martin (WRU) TMO: Claire Hodnett (RFU) |
| England v Canada The Stoop, Twickenham Sunday, 14 November, 2021 |
Referee: Hollie Davidson (SRU) Assistant Referee 1: Aurelie Groizeleau (FFR) Assistant Referee 2: Maria Giovanna Pacifico (FIR) TMO: Neil Paterson (SRU) |
| Ireland v Japan RDS Stadium, Dublin Saturday, 20 November, 2021 |
Referee: Clara Munarini (FIR) Assistant Referee 1: Sara Cox (RFU) Assistant Referee 2: Katherine Ritchie (RFU) TMO: Matteo Liperini (FIR) |
| France v New Zealand Stade Pierre Fabre, Castres Saturday, 20 November, 2021 |
Referee: Hollie Davidson (SRU) Assistant Referee 1: Aimee Barrett-Theron (SARU) Assistant Referee 2: Nikki O'Donnell (RFU) TMO: Neil Paterson (SRU) |
| Wales v Canada Cardiff Arms Park, Cardiff Sunday, 21 November, 2021 |
Referee: Aurelie Groizeleau (FFR) Assistant Referee 1: Maria Beatrice Benvenuti (FIR) Assistant Referee 2: Maria Giovanna Pacifico (FIR) TMO: Claire Hodnett (RFU) |
| England v USA Sixways, Worcester Sunday, 21 November, 2021 |
Referee: Julianne Zussman (RC) Assistant Referee 1: Doriane Domenjo (FFR) Assistant Referee 2: Francesca Martin (WRU) TMO: Ian Davies (WRU) |
| Barbarians Women v South Africa Twickenham Stadium, London Saturday, 27 November, 2021 |
Referee: Clara Munarini (FIR) Assistant Referee 1: Sara Cox (RFU) Assistant Referee 2: Maria Beatrice Benvenuti (FIR) TMO: Stefano Penne (FIR) |