Canada v USA
Saturday, 4 September, 2021
Swilers Rugby Club, St John's, Newfoundland		 Referee: Mike Adamson (SRU)
Assistant Referee 1: Moe Chaudhry (RC)
Assistant Referee 2: Robin Kaluzniak (RC)
TMO: Chris Assmus (RC)
USA v Canada
Saturday, 11 September, 2021
Infinity Park, Glendale, Colorado		 Referee: Mike Adamson (SRU)
Assistant Referee 1: Scott Green (USAR)
Assistant Referee 2: Luke Rogan (USAR)
TMO: Derek Summers (USAR)
USA v Uruguay 
Saturday, 2 October, 2021
Infinity Park, Glendale, Colorado		 Referee: Frank Murphy (IRFU)
Assistant Referee 1: Peter Martin (IRFU)
Assistant Referee 2: Scott Green (USAR)
TMO: Derek Summers (USAR)
Canada v Chile
Saturday, 2 October, 2021
Starlight Stadium, Langford, Victoria		 Referee: Chris Busby (IRFU)
Assistant Referee 1: Sean Gallagher (IRFU)
Assistant Referee 2: Moe Chaudhry (RC)
TMO: Chris Assmus (RC)
Uruguay v USA
Saturday, 9 October, 2021
Estadio Charrua, Montevideo		 Referee: Damian Schneider (UAR)
Assistant Referee 1: Tomas Bertazza (UAR)
Assistant Referee 2: Ricardo Caua (Brazil)
TMO: Santiago Borsani (UAR)
Chile v Canada
Saturday, 9 October, 2021
Estadio Elias Figueroa, Valparaiso		 Referee: Neheun Jauri Rivero (UAR)
Assistant Referee 1: Francisco Gonzalez (URU)
Assistant Referee 2: Gonzalo De Achaval (UAR)
TMO: Gabriel Pinter (UAR)